Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
6. “Taxi”(Jafar Panahi)
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
室内环境：这栋砖砌结构、灰泥粉饰并铺着瓷砖屋顶的两层楼房屋由Dorr & Dorr公司设计，于1916年完工，近15年内曾经翻修。该房屋采用了半牧场、半工匠艺术的设计风格，运用了简洁的线条、开敞式空间、典雅的木制品和彩色玻璃等设计。翻修工程由明尼阿波利斯市Sala建筑公司的约瑟夫·麦茨勒(Joseph Metzler)完成。
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
《患难与共》(Togetherness)，HBO，1月11日播出。HBO台的周日晚间喜剧组合中已经有了20出头的纽约女人（《都市女孩》[Girls]第四季第一集将在同一天晚上播出），还有快到30岁的旧金山男同性恋（《寻》[Looking]也在当天开播第二季）。现在又来了30多岁的洛杉矶异性恋者们。这部有点阴郁的半小时喜剧来自杰伊(Jay)和马克·杜普拉斯(Mark Duplass)，兄弟俩曾经合拍过《肥大的椅子》(The Puffy Chair)和《纸袋头》(Baghead)等诡异的电影。马克·杜普拉斯和梅兰妮·林斯基(Melanie Lynskey)饰演一对夫妻，和杜普拉斯最好的朋友（史蒂夫·齐西斯[Steve Zissis]饰演）与林斯基的姊妹（阿曼达·皮特[Amanda Peet]饰）合住一栋房子。
Trends and targets in antiviral phototherapy
The biggest falls in brand values include oil and gas companies, still suffering from low commodity prices, and banks, which face growing competition from rival payment systems such as PayPal — whose brand value increased by 35 per cent (see story page 2).
Coke's Kent is not the only chief executive who spoke out in 2013 about the merits of immigration reform for big business.
Take the intriguing reintroduction of “unfeigned regards” — last big in the 18th century and now found on emails from Indian help centres. But the winning sign-off, at the bottom of a message sent one Friday, was: “weekend well”. I nearly awarded it second prize for the best noun pretending to be a verb, though at the last minute this award was snatched by a consultant overheard saying: “Can we cold towel that?”
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
In China, WeChat has also lured more high-end users, a group that Tencent hasn't traditionally had a strong hold over.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
As stars such as Kevin Spacey and Morgan Freeman were alleged to have assaulted or harassed performers, activists began using the hashtag to share their ordeals online.
ACE2 as a potential therapeutic target for pandemic COVID-19
RSPCA South Australia chief inspector Andrea Lewis said it was a "heartbreaking" case for staff.
No. Ms Merkel may accept a small eurozone investment fund, but it will fall short of the French president’s ambitions. Mr Macron wants a “road map” to a budget equivalent to several percentage points of eurozone output, supervised by a finance minister, all to absorb economic shocks. Ms Merkel is inclined to acquiesce, but she has emerged politically weakened from federal elections and will be unable to impose such a decision on her largely sceptical public.
Diagnostic technologies for COVID-19: a review
By contrast, the strengthening of the Brazilian real helped the surge in coffee and sugar prices as the country is the largest producer of both.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Remedy: The tricky aspect of this regret is that it’s typically rooted in hindsight. Only after you’ve left the job and have moved on to something better, do you start beating yourself up for not making the leap sooner, even if it hadn’t been practical or possible. What you can do is to identify the factors that kept you in your former position as red flags to be aware of in the future and work to line up supports that will allow you to more quickly capitalize on other opportunities as they may present themselves. This could include reviewing and updating your resume with new accomplishments on a monthly or quarterly basis, keeping your LinkedIn account current, building up a contingency fund to allow you to feel less tethered to your current pay check and staying in the loop on industry news and gossip to be aware of where your skills and experience could be of value.
Promoting employment should be prioritized, said Premier Li Keqiang at a meeting organized by the Ministry of Human Resources and Social Security on last Friday.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
“We have not really assumed China will get better in the rest of the year,” said James Quincey, Coca-Cola’s chief operating officer. He said juice sales fell double digits in the second quarter in the country and Coca-Cola drinks dropped single digits.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
最佳乐队组合：Little Big Town
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
The drama won much praise for its use of slow motion when shooting martial arts.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
In terms of salary three years after graduation, Germany leads the way for masters in management programmes, with three schools in the top four. Graduates of WHU Beisheim have the distinction of earning the highest salary, at $98,123 on average.
Master of None
Cousins's deal qualifies as a blockbuster, the Raptors made two strong moves to bolster their contender status, and the race for the West's last playoff spot got far more intriguing, among other storylines.
Influenza neuraminidase: A druggable target for natural products
"According to our survey last year, only 0.6 to 0.7 percent of students at universities were thinking about starting their own companies. The number among vocational school students was as high as 2.2 percent. However, the idea of vocational students starting businesses is related more to creating jobs for themselves, and the majority of them have chosen to have online shops."
Insead is top of the 2017 Financial Times global ranking of the best 100 MBA programmes. It is the second year that the multi-campus international business school has taken the number one spot, after claiming it for the first time last year.
会。美国政府在垂直合并案上已有数十年没赢过。据美国司法部(Department of Justice)自己的审查指导原则，像时代华纳这样的内容所有者与AT&T这样的分销商之间的“垂直合并”，远不如水平合并那么令人担忧。与此同时，Facebook、亚马逊(Amazon)、Netflix和谷歌(Google)这四巨头（合称FANG，取每家名称首字母）如今主宰了数字娱乐版图，这使得政府的如下论点更难以站住脚：两家传统媒体公司的合并，会从根本上改变竞争态势。
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
1.《刺客聂隐娘》(The Assassin)与《疯狂的麦克斯4：狂暴之路》(Mad Max: Fury Road)，并列。侯孝贤和乔治·米勒(George Miller)导演了今年最好的两部商业片，二者都应该到你能找到的最大的屏幕上去看。
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
"I'm always amazed at how many people tell their co-workers about their job search," Kay says. "That's one of the worst things you can do." Ideally, you wouldn't tell any co-workers, but you may have to if you want them to serve as references. In that case, Kay says, "you need to pick people who you really trust, who don't have a hidden agenda and who won't let it slip."
Critics have been eager to point out that he is not so closely involved in new product development as his predecessor, and fails to elicit the same excitement when he takes to the stage to introduce them. But Mr Cook is aware of his shortcomings and has drawn on the worlds of fitness and fashion to assemble a new team of talents, including Angela Ahrendts, formerly of Burberry, and industrial designer Marc Newson.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Of the 200 nominated companies, 101 are privately-owned, while the rest are State-owned enterprises. The total value of these 200 listed brands has risen by 36 percent year-on-year to reach $696 billion, with the top 10 accounting for 46 percent of the total value.
This figure marks the highest rate of growth since 2011. As the total annual box office in China five years ago was only 10 billion yuan.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
I am so excited to be hosting the Oscars for the second time. You know what they say - the third time's the charm.
Inhibition of SARS coronavirus helicase by bismuth complexes
The lyrics are stupid, but who cares? Tom Jones sings like nobody's business, and pounds the theme to Thunderball out with a silky energy. It's powerful but alluring. This is the sort of song you imagine Bond would play on a jukebox when he's about to seduce you. There are better James Bond theme songs, but none from a male singer. Tom Jones and James Bond probably go out for dry martinis together all the time. They're the perfect pair.
Bella is the youngest model on the list, having just turned 21 last month.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
All held together with imported white stilton cheese, the flakes are interspersed on the pie with dollops of Ossetra caviar from the Caspian Sea as well as truffles and Fois Gras from France.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
All three factors, says Mr Koepke, were at work in the Mexican currency crisis of 1994-95, when the Fed embarked on a tightening cycle in jumps of 25, 50 and crucially, in November 1994, of 75 basis points.
今年由美国电影学会的电影评审总监是Tom Pollock，担任电视剧评审总监的是Richard Frank。评审团的其他成员还包括Judd Apatow, Halle Berry, Jamie Lee Curtis, Leonard Maltin,来自知名大学的著作家，学者，公认的电影艺术家，还有像媒体NPR,Rolling Stone, TV Guide, 华盛顿邮报对于电视电影的评论家们。
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
For starters, breaches like that of Bitstamp and the much larger (valued at about $400 million at the time) 2011 hack of the exchange Mt. Gox are often misconstrued as security issues with the currency itself. But they are only signs of flaws in those particular exchanges and not a sign of an issue with the underlying technology. And it is the underlying technology behind bitcoin that most excites. As we wrote in the “Shape the Future” package of our January 2015 issue, most of the vocal enthusiasts so bullish on bitcoin—from big-name entrepreneurs like Marc Andreessen to the developers and miners who spend their days refreshing the bitcoin Reddit page—are more interested in the applications that can be built on bitcoin’s “block chain,” the currency’s foundational backbone, than they are in bitcoin as a monetary system. The block chain allows the secure exchange of any form of value between two entities.
It also said 98 percent of government-sponsored students returned to China. Government-sponsored students who study abroad have chosen to pursue disciplines most needed in China, including engineering, the pure sciences, agriculture and medical science.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
14. 《与外婆同行》(Grandma)，导演：保罗·韦兹(Paul Weitz)。
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
I expect more companies to develop leaders who know how to manage networks — not just the traditional internal network of employees, but more loosely connected webs of suppliers and contractors, managed remotely via the internet and social media.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Joseph Keller、Raymond Goldstein、Patrick Warren和Robin Ball获此殊荣，他们的研究课题是“人类马尾辫中头发的运动及受力平衡”。
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
All-cash buyers. Skittish lenders. Skyrocketing prices. Anemic listings. These realities haunt buyers, turning the house hunt into a demoralizing slog. Unfortunately, buyers will probably have to soldier through another year of a market that favors sellers.
在根据真实罪案改编的电影《狐狸猎手》(Foxcatcher)中，以出演喜剧闻名的演员史蒂夫·卡瑞尔(Steve Carell)饰演大富翁约翰·E·杜邦(John E. du Pont)时隐藏在假面具后面。这个造型最突出的就是鸟嘴状鼻子。
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
In the meantime, the sheer total of bitcoin-related startups that launched in 2014 demonstrates bitcoin’s momentum. There is no definitive listing of every single bitcoin startup, but 2014 almost certainly saw the launch of more of them than in any year prior. Data that AngelList sent to Fortune confirms that. In 2011, five bitcoin startups listed themselves on AngelList. In 2012 that number grew to 13. In 2013 it jumped to 193, and last year it exploded to 566. (But not all startups register on AngelList immediately, if at all.) In addition, on January 8 the total number of daily bitcoin transactions hit an all-time high, as Barry Silbert eagerly tweeted.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Large technology companies were criticised throughout 2017 for becoming too powerful, using their size to dominate markets and not paying enough attention to how the tools they create can be used for ill.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
n. 宣言，声明 vi. 发表宣言
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
We need to ensure that our consumers will have access to good options, benefit from such consumption, and most importantly that Chinese companies will be able to win over the consumers with their commitment to high quality and workmanship.
A modular microarray imaging system for highly specific COVID-19 antibody testing
If he wins the primary, he would face off against first-term Republican Gov. Phil Scott, 59.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
It is a timely warning. His findings, he writes, “point to a heightened risk of emerging market crises in the coming years as the Fed continues to normalise interest rates”.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Finally, only two schools join the open ranking for the first time this year. Antai College of Economics and Management at Shanghai Jiao Tong University comes straight in at 32 and Eller College of Management at the University of Arizona is ranked 68th out of 75.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Despite the huge production, the focus was on the 40 gorgeous models who walked the runway.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
1.Mitsubishi. Brand love: -12% / Rank: 360
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Scientists confirmed Monday that a skeleton found under a carpark in the English city of Leicester was that of King Richard III, in a bizarre end to a 500-year-old historical mystery.
A facile assay for rapid detection of COVID-19 antibodies
Will businesses finally shed their caution?
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
And, men are 2.8 times more likely to use this obvious phrase than women.
China’s commercial aerospace ambition has long been known, but a few recent milestones are bringing it closer to realization.
其他机构有宝钢集团(Shanghai Baosteel Group)旗下为钢材交易商提供融资的欧冶云商(Ouyeel)、中国第六大银行招商银行(China Merchants Bank)旗下专注财富管理领域的小企业e家(Small Entrepreneur)等。
That deceleration could prove a spoiler to broader growth if it continues apace, as observers have attributed sustained activity growth among manufacturers to stronger domestic demand.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
The data measure how successful alumni have been in their career in terms of salary, seniority and achievements since graduating.
当芬兰程序员Jerry Jalava 2008年遇到车祸，他面临双重悲剧。首先，他失去了他的手指，对于靠打字生存的人来说是个大问题。其次，他必须跟一个幽默感过剩的医疗小组打交道。了解了他的遭遇后，一位外科医生竟然提议Jalava应该出门去买个“USB手指驱动器”。
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
In contrast to last year when the vast majority of economists expected the ECB to launch full-scale quantitative easing, just under half of the 33 respondents thought the ECB would do nothing this year. The rest said the ECB would expand QE or cut interest rates, although some of those who expected more easing stressed that the central bank was unlikely to radically reshape its existing policy response.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Online registration will end on Oct. 24. The exam will be held on Nov. 27 in major Chinese cities.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Length-scale dependence of protein hydration-shell density
'That's something that would be challenged, I think, in the 21st century.
I will be yours forever!我永远属于你！
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
They come mostly from 50 different industries including food and beverage, automobiles and auto components, media, retail, energy and the Internet.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
If you plan to visit Brazil for the Olympic games, and to focus on sport and having fun, Google has you covered. In anticipation of the 2016 Rio Olympics, the search giant is bringing the 'Explore' feature to Brazil Maps.
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