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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

adj. 自信的,有信心的,有把握的
但是这位少年依然没有放弃,他还留了最后一手。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

Gitanjali因为拿下了本次最高奖项,从而获得了一笔2.5万美元的奖金。
stress

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

From the themed collection: 展望:2016卫浴行业流行趋势
Open Access Perspective

Soft matter science and the COVID-19 pandemic

6. “Taxi”(Jafar Panahi)

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

室内环境:这栋砖砌结构、灰泥粉饰并铺着瓷砖屋顶的两层楼房屋由Dorr & Dorr公司设计,于1916年完工,近15年内曾经翻修。该房屋采用了半牧场、半工匠艺术的设计风格,运用了简洁的线条、开敞式空间、典雅的木制品和彩色玻璃等设计。翻修工程由明尼阿波利斯市Sala建筑公司的约瑟夫·麦茨勒(Joseph Metzler)完成。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

《患难与共》(Togetherness),HBO,1月11日播出。HBO台的周日晚间喜剧组合中已经有了20出头的纽约女人(《都市女孩》[Girls]第四季第一集将在同一天晚上播出),还有快到30岁的旧金山男同性恋(《寻》[Looking]也在当天开播第二季)。现在又来了30多岁的洛杉矶异性恋者们。这部有点阴郁的半小时喜剧来自杰伊(Jay)和马克·杜普拉斯(Mark Duplass),兄弟俩曾经合拍过《肥大的椅子》(The Puffy Chair)和《纸袋头》(Baghead)等诡异的电影。马克·杜普拉斯和梅兰妮·林斯基(Melanie Lynskey)饰演一对夫妻,和杜普拉斯最好的朋友(史蒂夫·齐西斯[Steve Zissis]饰演)与林斯基的姊妹(阿曼达·皮特[Amanda Peet]饰)合住一栋房子。
当年秋天开学后,达洛伊西奥开始感觉到肩上背负起了来自投资方的巨大压力。他需要改善软件的运算法则,于是他找到了以色列一个从事自然语言处理的编程团队,并签订了合同。他还用谷歌(Google)搜索找到了一位居住在泰国、在该领域有过重要著作的退休教授。达洛伊西奥说,他成了我们的科研主管,他现在在雅虎的森尼维尔办公室工作。
英国
Jude Webber

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

智能烤箱
The biggest falls in brand values include oil and gas companies, still suffering from low commodity prices, and banks, which face growing competition from rival payment systems such as PayPal — whose brand value increased by 35 per cent (see story page 2).
Coke's Kent is not the only chief executive who spoke out in 2013 about the merits of immigration reform for big business.
Take the intriguing reintroduction of “unfeigned regards” — last big in the 18th century and now found on emails from Indian help centres. But the winning sign-off, at the bottom of a message sent one Friday, was: “weekend well”. I nearly awarded it second prize for the best noun pretending to be a verb, though at the last minute this award was snatched by a consultant overheard saying: “Can we cold towel that?”

Graphical abstract: Trends and targets in antiviral phototherapy
From the themed collection: 到2022年城市落户限制逐步消除
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

Johan Pettersson被授予搞笑化学奖,以表彰其揭示了瑞典小城Andersl?v居民的头发会变绿的原因,因为这里的水中含铜量太大。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

In China, WeChat has also lured more high-end users, a group that Tencent hasn't traditionally had a strong hold over.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

As stars such as Kevin Spacey and Morgan Freeman were alleged to have assaulted or harassed performers, activists began using the hashtag to share their ordeals online.
Vawter 使用仿生腿在芝加哥一栋高楼里向上爬了103个阶梯,但是仿生腿的设计者们仍然在尝试提高它的性能。为了使它能适用于日常生活,设计者们必须让它更轻更薄。它的衍生品(充气仿生腿)可以满足陆军对于仿生腿的阶段性目标——行走一万步不用充电。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
From the themed collection: 2014年建材行业年度投资策略
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

RSPCA South Australia chief inspector Andrea Lewis said it was a "heartbreaking" case for staff.
No. Ms Merkel may accept a small eurozone investment fund, but it will fall short of the French president’s ambitions. Mr Macron wants a “road map” to a budget equivalent to several percentage points of eurozone output, supervised by a finance minister, all to absorb economic shocks. Ms Merkel is inclined to acquiesce, but she has emerged politically weakened from federal elections and will be unable to impose such a decision on her largely sceptical public.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

消费者的感觉变好。由于就业市场、楼市和股市状况的改善,消费者信心达到四年来的最高水平。美国陷入衰退后,美国人缩减债务,避免借钱并推迟购买。这意味着消费者需求增强的条件可能已经具备,进而可能促使停止招聘的企业开始扩员。信安环球投资有限公司的鲍尔说,企业可能尽可能地提高生产力增长,他表示雇主将需要增员来满足更强劲的需求。qh]
By contrast, the strengthening of the Brazilian real helped the surge in coffee and sugar prices as the country is the largest producer of both.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

Remedy: The tricky aspect of this regret is that it’s typically rooted in hindsight. Only after you’ve left the job and have moved on to something better, do you start beating yourself up for not making the leap sooner, even if it hadn’t been practical or possible. What you can do is to identify the factors that kept you in your former position as red flags to be aware of in the future and work to line up supports that will allow you to more quickly capitalize on other opportunities as they may present themselves. This could include reviewing and updating your resume with new accomplishments on a monthly or quarterly basis, keeping your LinkedIn account current, building up a contingency fund to allow you to feel less tethered to your current pay check and staying in the loop on industry news and gossip to be aware of where your skills and experience could be of value.
Promoting employment should be prioritized, said Premier Li Keqiang at a meeting organized by the Ministry of Human Resources and Social Security on last Friday.
产品看起来并不太像一个鼻子,而是一个瓶子,装满了培养细菌的营养液体。但是给这个“鼻子”一个血液样本,让它嗅上一段时间,这个瓶子的斑点会改变颜色来表示它鉴别出的细菌种类。
民主政体本质上是一种文明的内战。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

“We have not really assumed China will get better in the rest of the year,” said James Quincey, Coca-Cola’s chief operating officer. He said juice sales fell double digits in the second quarter in the country and Coca-Cola drinks dropped single digits.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
From the themed collection: 多项减税新举措助力企业轻装前行
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

最佳乐队组合:Little Big Town
可口可乐CEO穆泰康是第一代美国移民,同时也是业界的领袖人物。他认为移民改革对企业有好处。2月份,他在《今日美国》(USA Today)的评论版对页文章中表示,他庆幸自己能够在美国生活,而且他认为其他外国创业者也应该获得同样的机会。穆泰康写道,他支持移民改革的原因是移民“是这个伟大国家进步基石的关键组成部分。我们必须让决心来到美国、同时又拥有高超技能的人更容易在这里生存和生活下去。”

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

The drama won much praise for its use of slow motion when shooting martial arts.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

天生脑瘫的余秀华原本过着平静的乡村生活。现在,她在文坛引起了轰动,她描写情欲的生动诗歌“有明显的血污”。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

节目11 歌曲《我心永恒》,席琳-迪翁
In terms of salary three years after graduation, Germany leads the way for masters in management programmes, with three schools in the top four. Graduates of WHU Beisheim have the distinction of earning the highest salary, at $98,123 on average.
Master of None
Cousins's deal qualifies as a blockbuster, the Raptors made two strong moves to bolster their contender status, and the race for the West's last playoff spot got far more intriguing, among other storylines.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

"According to our survey last year, only 0.6 to 0.7 percent of students at universities were thinking about starting their own companies. The number among vocational school students was as high as 2.2 percent. However, the idea of vocational students starting businesses is related more to creating jobs for themselves, and the majority of them have chosen to have online shops."
Insead is top of the 2017 Financial Times global ranking of the best 100 MBA programmes. It is the second year that the multi-campus international business school has taken the number one spot, after claiming it for the first time last year.
“有个女员工打包好自己的东西就一言不发地走了。”
你一定有一个连走路时都念念不忘的怪癖。你只想聊这个。瞧着吧,观众会被你帅到的。
会。美国政府在垂直合并案上已有数十年没赢过。据美国司法部(Department of Justice)自己的审查指导原则,像时代华纳这样的内容所有者与AT&T这样的分销商之间的“垂直合并”,远不如水平合并那么令人担忧。与此同时,Facebook、亚马逊(Amazon)、Netflix和谷歌(Google)这四巨头(合称FANG,取每家名称首字母)如今主宰了数字娱乐版图,这使得政府的如下论点更难以站住脚:两家传统媒体公司的合并,会从根本上改变竞争态势。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
From the themed collection: 2016年陶瓷砖十大品牌最新排行榜
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

007系列电影主题曲第三名:阿黛尔--《天降杀机》
con全部,tain拿-全部拿住-包含

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

新加坡樟宜国际机场已经连续五年在每年一度的Skytrax世界机场大奖评选中获得世界最佳机场。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

1.《刺客聂隐娘》(The Assassin)与《疯狂的麦克斯4:狂暴之路》(Mad Max: Fury Road),并列。侯孝贤和乔治·米勒(George Miller)导演了今年最好的两部商业片,二者都应该到你能找到的最大的屏幕上去看。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

"I'm always amazed at how many people tell their co-workers about their job search," Kay says. "That's one of the worst things you can do." Ideally, you wouldn't tell any co-workers, but you may have to if you want them to serve as references. In that case, Kay says, "you need to pick people who you really trust, who don't have a hidden agenda and who won't let it slip."
我喜欢这个列表(很棒的观点),但是我觉得我要更详细的完善一下怎样成为一个高效老板或者经理。
2013年,公开表示移民改革对大公司有利的公司高管并不是只有可口可乐CEO穆泰康一人。
Critics have been eager to point out that he is not so closely involved in new product development as his predecessor, and fails to elicit the same excitement when he takes to the stage to introduce them. But Mr Cook is aware of his shortcomings and has drawn on the worlds of fitness and fashion to assemble a new team of talents, including Angela Ahrendts, formerly of Burberry, and industrial designer Marc Newson.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Of the 200 nominated companies, 101 are privately-owned, while the rest are State-owned enterprises. The total value of these 200 listed brands has risen by 36 percent year-on-year to reach $696 billion, with the top 10 accounting for 46 percent of the total value.
This figure marks the highest rate of growth since 2011. As the total annual box office in China five years ago was only 10 billion yuan.
加拿大城市温哥华依然是北美地区最贵城市,在生活成本指数榜单上名列第21位。
['seti?]

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
From the themed collection: 揭露家装建材业八大谣言
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

不过现在,她已经开始利用自己童话公主一般的面容做慈善事业了,她会装扮成童话角色的样子,为孩子们演出,为癌症患儿的家长加油鼓劲。
I am so excited to be hosting the Oscars for the second time. You know what they say - the third time's the charm.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

自从18个月前在亚洲设立业务以来,克拉布一直没有涉足香港房地产市场,因为他表示,价格太高了,可担负性太差。
The lyrics are stupid, but who cares? Tom Jones sings like nobody's business, and pounds the theme to Thunderball out with a silky energy. It's powerful but alluring. This is the sort of song you imagine Bond would play on a jukebox when he's about to seduce you. There are better James Bond theme songs, but none from a male singer. Tom Jones and James Bond probably go out for dry martinis together all the time. They're the perfect pair.
Bella is the youngest model on the list, having just turned 21 last month.
即使从未见过人微笑,盲人也会微笑。
北京、上海等城市都存在严重的空气污染问题。北京1月份爆发了近期最为严重的雾霾,而去年12月上海空气污染指数一度爆表。严重的空气污染问题显然无助于吸引更多外国游客前来旅游。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

All held together with imported white stilton cheese, the flakes are interspersed on the pie with dollops of Ossetra caviar from the Caspian Sea as well as truffles and Fois Gras from France.
清华大学公共管理学院主任杨燕绥表示,这4万亿元养老金结余很多都在个人账户里面,现收现付的养老保险制度遇到了抚养比的挑战。
大型企业PMI为53.1,比上月下降0.7个百分点;中型企业PMI为49.8,回落1.3个百分点,意味着进入轻度收缩。小型企业PMI为49,下降0.4个百分点,意味着收缩加剧。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

注册人数:503人
至少在城市大部分人能去上班是不可能的,这将影响多个行业,包括金融、广告、医疗保健和艺术。近两天城市的交通线路、桥梁、隧道都瘫痪了,在最新的报告中,地铁到下周可能会正常运作。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
From the themed collection: 广州7月租赁市场活跃
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

中国官方国内生产总值(GDP)增速会超过6.5%吗?
"这个家伙对当前情况作了利弊权衡:他有很大机会从故障电梯逃生,但是如果家庭作业没完成,他会很倒霉。"一名名为Zealshifang的用户调侃道。
effective

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

All three factors, says Mr Koepke, were at work in the Mexican currency crisis of 1994-95, when the Fed embarked on a tightening cycle in jumps of 25, 50 and crucially, in November 1994, of 75 basis points.
今年由美国电影学会的电影评审总监是Tom Pollock,担任电视剧评审总监的是Richard Frank。评审团的其他成员还包括Judd Apatow, Halle Berry, Jamie Lee Curtis, Leonard Maltin,来自知名大学的著作家,学者,公认的电影艺术家,还有像媒体NPR,Rolling Stone, TV Guide, 华盛顿邮报对于电视电影的评论家们。
这是007系列电影最佳主题曲之一,但实际上并没有在片头演奏,所以我们把它放在荣誉推荐的第一位。这首浪漫的曲子呼应了电影情节的发展,最终詹姆斯·邦德遇到了真爱。(可惜他们的恋情维持不久便结束了。)路易斯·阿姆斯特朗运用了他标志性的颤音,听者心弦颤动,一个经典诞生了。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
From the themed collection: 北京将建欺骗公证黑名单查询系统
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

《哈利·波特》粉们,福利来啦!该片是《哈利·波特》前传,讲述了纽特·斯卡曼德在老纽约的冒险经历。该片根据《哈利·波特》中霍格沃兹学院的同名教科书改编而成。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

在7月31日的分析师电话会议上,特斯拉的董事长兼CEO埃隆o穆斯克亲手给“特斯拉热”又添了一把柴。这次会议上爆出的“大新闻”并不是特斯拉第二季度产量再次提升并超过了收益预期。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
From the themed collection: 广东累计缴存公积金超1.5万亿元
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

vt. 打斗
根据全球最大航运公司马士基航运公司(Maersk Line)的数据,从汽车到集装箱运输的纺织品,1月中国对巴西出口同比下降60%,而通过集装箱进入拉美最大经济体的总进口量减半。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

['?p?reit]
For starters, breaches like that of Bitstamp and the much larger (valued at about $400 million at the time) 2011 hack of the exchange Mt. Gox are often misconstrued as security issues with the currency itself. But they are only signs of flaws in those particular exchanges and not a sign of an issue with the underlying technology. And it is the underlying technology behind bitcoin that most excites. As we wrote in the “Shape the Future” package of our January 2015 issue, most of the vocal enthusiasts so bullish on bitcoin—from big-name entrepreneurs like Marc Andreessen to the developers and miners who spend their days refreshing the bitcoin Reddit page—are more interested in the applications that can be built on bitcoin’s “block chain,” the currency’s foundational backbone, than they are in bitcoin as a monetary system. The block chain allows the secure exchange of any form of value between two entities.
时间:2009-11-09 编辑:vicki
It also said 98 percent of government-sponsored students returned to China. Government-sponsored students who study abroad have chosen to pursue disciplines most needed in China, including engineering, the pure sciences, agriculture and medical science.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

14. 《与外婆同行》(Grandma),导演:保罗·韦兹(Paul Weitz)。
该项目的另一个好处在于,它鼓励了职业灵活性,让年轻人对曲折的职业道路有所准备,而后者可能在现代职场中是必不可少的。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

I expect more companies to develop leaders who know how to manage networks — not just the traditional internal network of employees, but more loosely connected webs of suppliers and contractors, managed remotely via the internet and social media.
越南昆岛——越南昆岛曾是臭名昭著的昆岛监狱所在地,由16座独立的小岛组成;现在,它的美景及海鲜正变得越来越有名气。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

Joseph Keller、Raymond Goldstein、Patrick Warren和Robin Ball获此殊荣,他们的研究课题是“人类马尾辫中头发的运动及受力平衡”。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

All-cash buyers. Skittish lenders. Skyrocketing prices. Anemic listings. These realities haunt buyers, turning the house hunt into a demoralizing slog. Unfortunately, buyers will probably have to soldier through another year of a market that favors sellers.
支出提升三成是由更专业的创新药品,更多患者支付得起药品以及放宽专利期限这些因素驱动的。
在根据真实罪案改编的电影《狐狸猎手》(Foxcatcher)中,以出演喜剧闻名的演员史蒂夫·卡瑞尔(Steve Carell)饰演大富翁约翰·E·杜邦(John E. du Pont)时隐藏在假面具后面。这个造型最突出的就是鸟嘴状鼻子。
这是5年来非合办EMBA项目首次跻身前5名,全球EMBA项目前5名的名次非常稳定。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

In the meantime, the sheer total of bitcoin-related startups that launched in 2014 demonstrates bitcoin’s momentum. There is no definitive listing of every single bitcoin startup, but 2014 almost certainly saw the launch of more of them than in any year prior. Data that AngelList sent to Fortune confirms that. In 2011, five bitcoin startups listed themselves on AngelList. In 2012 that number grew to 13. In 2013 it jumped to 193, and last year it exploded to 566. (But not all startups register on AngelList immediately, if at all.) In addition, on January 8 the total number of daily bitcoin transactions hit an all-time high, as Barry Silbert eagerly tweeted.
杨金秀(Olive Yang)

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

Large technology companies were criticised throughout 2017 for becoming too powerful, using their size to dominate markets and not paying enough attention to how the tools they create can be used for ill.
谎言4:太感谢了!我很喜欢!说谎原因:告诉别人他们送的礼物一团糟会让我看起来像是冷血的混蛋。
n. 鼓励

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

n. 宣言,声明 vi. 发表宣言
立场:为禁止员工在家上班进行辩解
007系列电影主题曲第二名:蒂娜·特纳--《黄金眼》

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
From the themed collection: LED照明行业新三板上市热
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

n. 青少年
实际上,有能力和平回应是它们的长处之一。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

We need to ensure that our consumers will have access to good options, benefit from such consumption, and most importantly that Chinese companies will be able to win over the consumers with their commitment to high quality and workmanship.
并非所有评委都认同该书提出的解决方案,但无人质疑其论点的力量。
会。梅因为失算的提前选举而失去了大部分权威。但过去几个月情况对她较为有利。敲定退欧离婚协议,确保了她的饭碗短期无忧。因此直到2019年英国退欧正式完成(或者另一种更吸引人的替代方案出现)前,保守党将让她继续坐在首相位置上。留欧派和退欧派都希望避免因反对她而引发内战。事实将证明,曾经被人们认为是坐不长的位置,意外地能够坐久。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

If he wins the primary, he would face off against first-term Republican Gov. Phil Scott, 59.
该研究基于数亿个安全问题的答案以及数百万条恢复账号登录的请求。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

单词compromise 联想记忆:
添加方式1.扫描上方可可官方微信二维码。
It is a timely warning. His findings, he writes, “point to a heightened risk of emerging market crises in the coming years as the Fed continues to normalise interest rates”.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Finally, only two schools join the open ranking for the first time this year. Antai College of Economics and Management at Shanghai Jiao Tong University comes straight in at 32 and Eller College of Management at the University of Arizona is ranked 68th out of 75.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 隐藏在橱柜中的铰链的“秘密”
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

当小李子上台领取奖杯时,制片人哈维韦恩斯坦兴奋地拍拍他的背,全场观众起立为他喝彩。
尽管在奥巴马担任美国总统的过去的四年里,美国经济复苏缓慢、失业率居高不下,奥巴马在几个关键的摇摆州获得的选票还是高于罗姆尼。美国选民在两种风格明显迥异的国家发展愿景中做出了自己的决定。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

注册营养师艾利克斯?图鲁夫称:“糖屑中含有糖分,而金片与此不同,它不含碳水化合物、脂肪或蛋白质,所以不能提供热量,没有味道,主要用于装饰。”
Despite the huge production, the focus was on the 40 gorgeous models who walked the runway.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

参与本次突袭犯罪活动的警察说,他们还发现了牛百叶、软骨和其它早已过期的动物器官,这些都是从邻国越南走私来的。警方共查处非法肉类20吨。
1.Mitsubishi. Brand love: -12% / Rank: 360

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

adj. 乐观的,乐观主义的
Scientists confirmed Monday that a skeleton found under a carpark in the English city of Leicester was that of King Richard III, in a bizarre end to a 500-year-old historical mystery.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Will businesses finally shed their caution?

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
From the themed collection: 木塑复合材料:绿色建筑的领头羊
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

And, men are 2.8 times more likely to use this obvious phrase than women.
China’s commercial aerospace ambition has long been known, but a few recent milestones are bringing it closer to realization.
其他机构有宝钢集团(Shanghai Baosteel Group)旗下为钢材交易商提供融资的欧冶云商(Ouyeel)、中国第六大银行招商银行(China Merchants Bank)旗下专注财富管理领域的小企业e家(Small Entrepreneur)等。
That deceleration could prove a spoiler to broader growth if it continues apace, as observers have attributed sustained activity growth among manufacturers to stronger domestic demand.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
From the themed collection: 高端散热器技术落户中国
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

源于:strike(v 打击;军事进攻;铸造;敲钟;罢工)

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

开发商:Frontier、Microsoft Studios
The data measure how successful alumni have been in their career in terms of salary, seniority and achievements since graduating.
当芬兰程序员Jerry Jalava 2008年遇到车祸,他面临双重悲剧。首先,他失去了他的手指,对于靠打字生存的人来说是个大问题。其次,他必须跟一个幽默感过剩的医疗小组打交道。了解了他的遭遇后,一位外科医生竟然提议Jalava应该出门去买个“USB手指驱动器”。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

这是第二枚被拍卖的诺贝尔和平奖奖牌,得主是第一个获得该奖项的拉美人——1936年诺贝尔和平奖奖牌被授予当年的阿根廷外长卡洛斯·萨维德·拉莫斯。
In contrast to last year when the vast majority of economists expected the ECB to launch full-scale quantitative easing, just under half of the 33 respondents thought the ECB would do nothing this year. The rest said the ECB would expand QE or cut interest rates, although some of those who expected more easing stressed that the central bank was unlikely to radically reshape its existing policy response.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

adj. 快的,迅速的
Online registration will end on Oct. 24. The exam will be held on Nov. 27 in major Chinese cities.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

国务院总理李克强在上周五由人力资源和社会保障部组织的一次会议上表示,要优先促进就业。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

本周二在竞选的最后阶段,罗姆尼还前往俄亥俄州和宾夕法尼亚州,希望能在这些摇摆州取得选票支持。奥巴马竞选阵营这边,副总统拜登也前往了俄亥俄州,奥巴马本人留守芝加哥。
1.尼泊尔
对于共同创始人哈勃,未来12个月的第一要务是强化Bigcommerce的内部科技人才队伍,提供能够帮助商户构建更紧密客户关系的服务。一个例子是提供数据,帮助店铺经理追踪“被丢弃的购物篮”,以及提供能够将浏览者转变为买家的交易。这能推动商户的月销售额迅速增加15%,他说。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

几年前,有人发明了一辆会飞的自行车,叫做"Paravelo"。称一辆自行车会飞,并不是开玩笑,而是这辆自行车真的会飞(车头有一个巨大的降落伞)。它在陆地和空中的时速分别为25千米(15英里)和40千米(25英里),可飞至1200米(4000英尺)高空。最棒的地方是什么呢?那就是你不需要有飞行驾照。Paravelo号称世界上第一辆会飞的自行车,但我们必须指出它并不是第一辆会飞的自行车。
'That's something that would be challenged, I think, in the 21st century.
I will be yours forever!我永远属于你!
Company: Eventbrite

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

They come mostly from 50 different industries including food and beverage, automobiles and auto components, media, retail, energy and the Internet.
然后,他用那把小提琴砸穿了那幅画。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

['i?ju:]
公司:The Grommet公司
If you plan to visit Brazil for the Olympic games, and to focus on sport and having fun, Google has you covered. In anticipation of the 2016 Rio Olympics, the search giant is bringing the 'Explore' feature to Brazil Maps.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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About this collection

华盛顿(市场观查者)—美国经济2014年迎来了自二战后最曲折的复苏而且年末能源方面又遇到了大的波折,但是2015年美国经济将披荆斩棘变得更好。
高中版的霍华德不像NBA版的霍华德那样令人生畏。如此看来,成为一个NBA巨星,霍华德付出了十倍的努力。

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