Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
I can well imagine that in 2016 the oil price will bounce back from its current sub $40 level. The Saudis may try to cut production, there could be more conflict in Iraq, terrorists could attack some of the prize targets such as the oil terminals at Ras Tanura and Abqaiq. Anything is possible, something is likely. But the question is how far the bounce will go.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
But despite the anticipation, it seems the underwear brand's debut in the Chinese city is not going entirely to plan.
The release of Apple's iPhone 6s and 6s Plus models in September led to record sales in China, which accounts for more than a fourth of the company's operating income. Apple, whose products are often viewed as status symbols in China, is in competition not just with its South Korean archrival Samsung, but with the increasingly popular Chinese smartphone makers Huawei and Xiaomi.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
But perhaps we are finally there. Perhaps the curtain had to fall on the show before it could fall on that part of the ready-to-wear shows. Perhaps the history hamster wheel that we seem to be on — which has seen us cycle through the 1970s as well as some of the big hair and bigger shoulder pads of the 1980s (yes, we are there again) — will finally stop turning.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
从某些方面来看，《生活真奇怪》（Life Is Strange）与Dontnod Entertainment的科幻动作类游戏《勿忘我》（Remember Me）是两款截然不同的游戏，而从另一些方面来看，这两款章节式的冒险游戏十分类似。两款游戏都采用了虚幻3引擎（Unreal Engine 3），打造了美轮美奂的游戏世界供玩家探索。这两款游戏的名字也都有非常具有女性特征的主角。《生活真奇怪》的故事发生于美国俄勒冈州的阿卡迪亚湾，玩家将操纵青年马克斯o考菲尔德，开始一段包含有五个章节互动剧情的冒险。
Here's a look into social media's crystal ball for 2014. Will Snapchat catch fire? Will those annoying Promoted Tweets keep invading your Twitter stream? Will your boss finally learn to tweet? These five trends are poised to shake up the industry and the way we use social media in 2014:
Trends and targets in antiviral phototherapy
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
10.Michigan's Upper Peninsula, the US
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
《患难与共》(Togetherness)，HBO，1月11日播出。HBO台的周日晚间喜剧组合中已经有了20出头的纽约女人（《都市女孩》[Girls]第四季第一集将在同一天晚上播出），还有快到30岁的旧金山男同性恋（《寻》[Looking]也在当天开播第二季）。现在又来了30多岁的洛杉矶异性恋者们。这部有点阴郁的半小时喜剧来自杰伊(Jay)和马克·杜普拉斯(Mark Duplass)，兄弟俩曾经合拍过《肥大的椅子》(The Puffy Chair)和《纸袋头》(Baghead)等诡异的电影。马克·杜普拉斯和梅兰妮·林斯基(Melanie Lynskey)饰演一对夫妻，和杜普拉斯最好的朋友（史蒂夫·齐西斯[Steve Zissis]饰演）与林斯基的姊妹（阿曼达·皮特[Amanda Peet]饰）合住一栋房子。
ACE2 as a potential therapeutic target for pandemic COVID-19
The annual rich list of China's movers and shakers gives a temperature check on where money is flowing in China, and underlines the growing financial muscle of the country's super-rich.
James Bond is one of the few constants that movie lovers have in this crazy world of ours. We seem to know that, no matter what, a new Bond movie is always on the way.
Diagnostic technologies for COVID-19: a review
What’s in a shade? If you are Pantone, the “color authority” and the dominant color trend forecaster, and you get to choose a “color of the year” every year, potentially a lot. It could include determining fashion’s direction (these are the hues that inform the fabrics that get bought by designers that get made into your clothes), influencing interiors, and even affecting how food appears. Still, I don’t think I’ve ever seen quite so much political and philosophical import attached to a color decision as I have for the 2016 “Color of the Year.”
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
I don't know about you, but if I had a separate calendar for work, school and life, I'd be a complete mess. When everything in your life is on one calendar, in one planner, you can't double-book anything. You know, like an important test and a dinner with your boss.
In this post, we’ll take a look at 16 software applications that I use almost every day — and discuss why you should too.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
1. Newspaper reporter
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Not a lot of Bond villains get their own theme song, but Christopher Lee's assassin from The Man with the Golden Gun gets a flashy, catchy, groovy tune that makes him seem cool as hell. (And of course, he is.) Lulu completely sells the awesomeness of the villain Scaramanga, and although the song may seem almost ridiculously upbeat today, it only adds to the charm.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
Social network Facebook Inc., e-commerce giant Amazon and toy company Lego were the top-growing brands.
Except your Watson, he thinks it's hot.
Influenza neuraminidase: A druggable target for natural products
Nearly four in 10 US residents say the severity of recent natural disasters such as Superstorm Sandy is evidence the world is coming to an end, as predicted by the Bible, while more than six in 10 blame it on climate change, according to a poll released on Thursday.
The other sex toy apparently belonged to a Chinese imperial family.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
As for liberalization of global trade, we believe all countries need to work together to push it forward. This globe belongs to us all and we all need to do our bit.
The role of biosensors in the detection of emerging infectious diseases
Wright is one of the most original figures of British Romantic painting, and this composition, held in the same private collection in Derbyshire since 1840, had an approachable low estimate of 100,000 because of condition issues and — not insignificantly — the fact that it was a charity donation to benefit Syrian refugees. As a result, at least three bidders pushed the price to 665,000 with fees.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Domestic action movie "Wolf Warrior II" was top on the list and became the country's highest-grossing film ever, raking in 5.68 billion yuan in ticket sales.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The most exciting part is the offseason
Song “The Sacred Land” (Sun Nan)
The ECB ended the year with a vote on December 3 to cut its deposit rate to minus 0.3 per cent and an expansion in asset purchases that leaves its quantitative easing programme at 1.46tn. The move came days before the US Federal Reserve increased interest rates for the first time since 2006, underlining the sharply divergent policies being pursued on either side of the Atlantic.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Emissions have been falling gradually in recent years in most of the developed countries, in part because of economic weakness but also because of strengthening climate policies. Emissions in the 28-nation European Union fell 1.8 percent in 2013, despite increases in coal consumption in a few countries, including Germany and Poland. Emissions decreased sharply in Britain, Italy and Spain.
节目32 歌曲《给我你的爱》，张杰 林宥嘉
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Make sure you've got a good plan for seeing that your children are cared for when you're scheduled to be in class, and when you need to study. It really is possible to raise children while you're going to school. People do it every day.
Inhibition of SARS coronavirus helicase by bismuth complexes
Not until recently anyway. But scientists at Weill Cornell Medical College have at last managed to—at least with mice and monkeys. This produced artificial retinas, whose chips convert images into electronic signals and whose tiny projectors convert electronic signals into light.
China's box office sales have increased from 1 billion yuan to 40 billion yuan in the past decade as the industry has adopted more market-oriented reform measures.
4. "The Big Bang Theory" (3.4 million)
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
The mattress comes with sensors inside the bed that can detect pressure and send messages to the app, which spares no details. The app not only detects movement on the bed, but also records the intensity and speed at which people are getting it on.
"Last year, 1.2 million Chinese visited Australia. We anticipate this will grow during the China-Australia Year of Tourism and will continue to grow afterward."
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Foreign investment in emerging markets has dropped to the lowest level since the financial crisis as investors are braced for the fallout of the first US interest rate rise in nearly a decade.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Finally, in the EMBA ranking, excluding joint programmes delivered with non-European schools, IMD of Switzerland, with an average salary of $261,397, is well ahead of Business School in second and IE Business School in third place.
Perhaps my favorite profile this year was Kiki Zhao’s stirring depiction of the remarkable Yu Xiuhua, now one of China’s most read poets, a woman with cerebral palsy who lived most of her 41 years on a farm, writing at a low table. She never finished high school, and says she “could write before she could read.” Now, she is invited to places like Stanford University and fends off comparisons to Emily Dickinson.
The public prosecutor has decided to release several individuals and will proceed with the prosecution of at least five others.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
In 2018, more business leaders will channel a potent combination of digitalisation, generational change and growing diversity, to streamline their hierarchies, distribute responsibility, and transform their organisations.
The identity of the people buried in the cemetery is a mystery. The cemetery had been robbed in the past and no writing was found that indicates the names of those buried or their positions in life.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
"He said if he didn't get that package within the next 53 years, he would call to complain," university spokeswoman Christine Kindl told Reuters news agency.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
The pay gap has increased to 17 per cent, with women on an average of $170,000 compared with nearly $200,000 for men.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
es to you and yours.以我所有的爱心与真诚祝你及全家圣诞快乐。
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
More than an hour into Apple’s annual shareholder meeting in February, Tim Cook had patiently fielded questions ranging from its plans for the television market to what he thought of Google Glass. But when one audience member tried to push Apple’s chief executive on the profitability of Apple’s various environmental initiatives, such as its solar-powered data centre, Mr Cook snapped.
"Everywhere I go business owners are seeing an increase in demand," said Gus Faucher, senior economist at PNC Financial Services. "Businesses will have to raise wages to attract or maintain workers."
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Over time, this ethnic blend has led to an uncommon harmony among the current squad, whose young players -- notably Eden Hazard and Romelu Lukaku of Chelsea, and Adnan Januzaj 贾努扎伊of Manchester United -- are the envy of many of their competitors.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
It's a bit of a lark organised by UK film critics – a gong for the top canine performance at the festival, handed out on the last Friday in the British pavilion. This year the Palm Dog went to Lucky, a Maltipoo – that's half Maltese terrier, half poodle – who plays Dixie in Miguel Gomes' six-hour epic, Arabian Nights. The prizewinner is presented with a toy bone and this year delivered a brief acceptance speech (“woof”) by video link. A jolly time was had by all but an unnamed French journalist felt that the award was “an unwanted intrusion of British silliness” in the glamorous proceedings, according to AFP. “From the French perspective, this is a bit bizarre,” he is reported to have said. “The British are weird.”
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
According to historical accounts, Richard's body was transported naked and bloody on the back of a pack horse to Leicester before being buried in an unmarked grave at Greyfriars, a Franciscan friary in the central English city.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
After 'Gravity' and 'American Hustle,' my picks are in alphabetical order:
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Care about them, but don't let on mkay?
5. You're taking four-hour lunches and have way too many dentist appointments。
A modular microarray imaging system for highly specific COVID-19 antibody testing
10. Are YOU Re-Energized?
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
迷你剧集/电影类最佳男演员：考特尼?B?万斯(Courtney B Vance)，《美国罪案故事：公诉辛普森》(The People v. O. J. Simpson: American Crime Story)
The study relied on a dataset of hundreds of millions of secret answers and millions of account recovery requests.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
圣加伦大学在总排名上仍居榜首，这是这家瑞士商学院的战略及国际管理硕士项目连续第七年夺冠。巴黎高等商学院连续第四年屈居亚军，西班牙IE商学院(IE Business School)的排名上升四位，至第三。
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
6.The Stock Market Plunge
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
But that kind of emotional identification gets lost on the runway, and the retail floor. And then we are left with what?
节目25 歌曲《风吹麦浪》，李健 孙俪
A facile assay for rapid detection of COVID-19 antibodies
The IOM says fewer than 35,000 migrants, or about three percent, have crossed by land into Greece and Bulgaria from Turkey.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
“I saw a woman die and I saw the president of the United States refuse to unequivocally condemn the people who killed her.”
The Belty is great that it uses technology to track fitness, water intake, and posture, but for $395, you might be better off getting the same in a stylish smart watch or activity tracker.
Dealers: Car dealers work toward reducing the paperwork involved in buying a car and the hours it takes to fill it out. That will give them more time to devote to upselling add-ons such as extended warranties, paint and fabric protection, and rust-proofing.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
节目26 相声剧《搭把手不孤独》，冯巩 郭冬临 闫学晶
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
201103/129769.shtmlEveryone tells a white lie on occasion, it’s just a question of why. Some white lies save relationships, some ease a hectic situation, and others buy us time. We all do it, so there is no reason to deny it. As long as we aren’t hurting others or breaking the law, these innocent lies can make life more pleasant. Most of these white lies only stretch aninterpretation of what the truth actually is anyways. Here’s a list of the 10most common white lies and why we tell them.
Anti-HIV drug repurposing against SARS-CoV-2
挪威曾为一只企鹅授予爵位。它现在居住在苏格兰的爱丁堡动物园，是那里的企鹅王，它叫尼尔斯·奥拉夫（ Nils Olav）。它不仅是一只吉祥物，更是挪威皇家护卫队的名誉上校。2008年8月15日，国王哈拉尔五世（King Harald V）授予奥拉夫爵位，并在授予典礼上声明“奥拉夫在各方面都有资格获得骑士爵位的荣誉和尊严”。
Length-scale dependence of protein hydration-shell density
Tongzhou was designated as the site of a new administrative center for the municipal government to help relieve the current heavy pressure on public services in downtown Beijing, where the central government is located.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Best Companies rank: 63
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Do you routinely roll your eyes? Do you have a weak handshake? Do you avoid making eye contact? These could all be career killers. People must understand that actions speak louder than words. And the majority of our communication is done through non-verbal cues. People could perceive some of your non-verbal communication habits as rude or unprofessional—and these things could eventually have a significant impact on the advancement of your career.
About this collection
Trium跃升3名，击败由凯洛格管理学院(Kellogg School of Management)与香港科技大学(HKUST)联合推出的课程，后者多年来一直高居排行榜榜首。这是Trium首次登上排行榜榜首，也是14年来第四个登上榜首的课程。